Clipmarks | Prion Clips

遺伝子の変異でプリオンに伝播性が

Mon, 31 Aug 2009 00:30:30 GMT

clipped by: aramah

For the first time, Whitehead Institute researchers have shown definitively that mutations associated with prion diseases are sufficient to cause a transmissible neurodegenerative disease.

The discovery is reported in the August 27 edition of the journal Neuron.

Until now, two theories about the role mutations play in prion diseases have been at odds. According to one theory, mutations make carriers more susceptible to prions in the environment. Alternatively, mutations themselves might cause the disease and the spontaneous generation of transmissible prions.

The mutated gene engineered by Jackson had created a transmissible prion disease that could not be attributed to any prions in the environment.

Factual reasons to avoid all Genetically Modified Foods

Sat, 27 Jun 2009 05:35:06 GMT

clipped by: echeryl
clipper's remarks: We have got to take a stand before everyone of our children are sterile or diseased!

Clip Source: articles.mercola.com

GM cotton not only contained the intended protein produced by the Roundup Ready® gene, but also extra proteins that were not normally produced in the plant. These unknown proteins had been created during the gene insertion process.

Gene insertion was done using a gene gun (particle bombardment)

a kind of barbaric and messy method of genetic engineering, where you use a gun-like apparatus to bombard the plant tissue with genes that are wrapped around tiny gold particles." He knew that particle bombardment can cause unpredictable changes and mutations in the DNA, which might result in new types of proteins.

The scientist dismissed these newly created proteins in the cotton plant as unimportant

Proteins can have allergenic or toxic properties, but no one at Monsanto had done a safety assessment on them. "I was afraid at that time that some of these proteins may be toxic." He was particularly concerned that the rogue proteins "might possibly lead to mad cow or some other prion-type diseases

Two deer test positive for CWD

Mon, 09 Feb 2009 23:05:22 GMT

clipped by: shankargallery
clipper's remarks: more CWD & prion diseases spreading

Clip Source: www.hotspringsstar.com

Two deer test positive for CWD

City receives permit to kill 50 additional animals

By Curt Nettinga Tuesday, February 03, 2009

a whiff of mad cow

Sun, 28 Dec 2008 05:02:59 GMT

clipped by: doodleicious

Clip Source: sciencenow.sciencemag.org

A Whiff of Mad Cow

Prions get the bad reputation--and the lion's share of research attention--but interest in the normal form of prion proteins is increasing. Brain tissue is particularly high in these proteins, and a growing body of research has shown that they help neurons conduct copper and may even protect them from destruction by rogue chemicals in the body. But no one had pegged prion proteins to a particular neurological function such as sight or smell.

Showing that the normal prion protein plays a role in an animal's sense of smell is an important contribution, because it pegs the protein to an actual neurophysiological process, says Gerald Zamponi, a molecular neurophysiologist at the University of Calgary in Canada. "This is the first description of true change in a physiological response" due to this protein, he says, whose healthy function has been very tough to pin down.

Tags: science

New BSE cases blamed on ineffective feed ban

Thu, 22 May 2008 21:26:48 GMT

clipped by: shankargallery
clipper's remarks: New BSE cases blamed on ineffective feed ban
Edmonton Journal - Edmonton,Alberta,Canada
Banning ruminant-to-ruminant feed reduces the chance of cattle ingesting the abnormal, disease-causing prion that causes the disease.

Clip Source: www.canada.com

New BSE cases blamed on ineffective feed ban

The Edmonton Journal

Published: Sunday, May 18

12 BSE cases uncovered since May 2003, at least half are BABs -- born after the ban -- a development that raises serious questions about the efficacy of the 1997 feed ban which prohibited the risky practice of feeding rendered cattle parts to cattle.

Vendors Hesitate to Sell US Beef

Tue, 13 May 2008 17:53:51 GMT

clipped by: shankargallery
clipper's remarks: Vendors Hesitate to Sell US Beef
코리아타임즈 - South Korea
... likely to contract variant Creutzfeld Jacob Disease (vCJD) • thought to be caused by prion transmission from BSE infected cows than Westerners

Clip Source: www.koreatimes.co.kr

Vendors Hesitate to Sell US Beef

Military, Schools and Hospitals Concerned Over Safety

By Jung Sung-ki

Consumer worries about the safety of U.S. beef are likely to dampen future sales here.

Creekstone Farms Request for 100% BSE Testing Denied

Tue, 13 May 2008 04:22:02 GMT

clipped by: shankargallery
clipper's remarks: Iowa tv same old story,no to prion testing

Clip Source: www.iptv.org

Creekstone Farms Request for 100% BSE Testing Denied

SHOW TAPED ON: August 27, 2004

U.S. negotiators will be back in Tokyo soon to try and broker a deal that would ease Japan's insistence on 100 percent testing of cattle for Mad Cow disease. Japan has blocked imports of U.S. beef since a single case of Mad Cow was found in the States last December. Japan says 100 percent testing is needed to prevent contaminated beef from entering the human food chain. The U.S. says such blanket testing is unnecessary.

Tags: madcow, prion, testing

donated blood: invention to elimate "mad-cow disease" risk

Tue, 13 May 2008 00:05:55 GMT

clipped by: Don_Fatigue
clipper's remarks: I´m happy to hear !

Clip Source: news.scotsman.com

Scots doctors pioneer trial to remove 'mad cow' risk from donated blood

THE world's first trial to make blood transfusions free of the human form of 'mad cow disease' has been launched by doctors in Scotland.

Scotland on Sunday can reveal that heart patients in Edinburgh who need blood will be offered donations which have been 'cleaned' in a filter to remove the proteins – or prions – which cause variant Creutzfeldt-Jakob disease.

The trials are being undertaken by the Scottish Blood Transfusion service using a filter developed by an international medical supplies firm MacoPharma. The device, which works in a similar way to a coffee filter, removes the prions which cause the disease from donated blood.

It is believed that at least 1,200 Scots have vCJD, a fatal disease that causes brain damage, but do not yet know it.

Tests on the prion filter using animals have so far shown that it prevents the prions being passed on from a blood donor to a recipient.

Tags: medical, mad-cow disease, prevention, trial, blood donor, creutzfeld-jakob, filter, prions

Levels Of Prion Protein In Brain May Not Be Reliable Marker For Disease

Mon, 24 Dec 2007 05:31:35 GMT

clipped by: etcrisis

Clip Source: www.sciencedaily.com

Rona Barron and colleagues tested whether abnormal PrP and infectivity was an absolute association. They injected mice with two different strains of prion-infected tissue and quantified the degree of infection in these mice.

Next, they examined the amount of abnormally folded PrP in brains of the sick mice and found that it did not correlate in any way with how infectious the disease strain was; in fact, some highly infectious tissue samples had nearly undetectable levels of abnormal PrP.

These data suggest that not all abnormal PrP found in diseased tissues is infectious, and may instead be a pathologic by-product of disease. Some other agent, or a specific conformation of abnormally folded PrP, may therefore be responsible for prion disease

MAD COW

Thu, 25 Oct 2007 06:43:52 GMT

clipped by: shivas86

Clip Source: www.anomalies-unlimited.com

Millions of cows (and sheep) have been killed in Great Britian and other European countries in the past 15 years to preven the spread of two diseases; millions of chickens have been killed in China for the same reasons. The first is known as "Mad Cow", or Bovine Spongiform Encephalopathy (BSE) in which actual holes are found in the animal's brains. The human form of this goes by the less-obvious name of Creutzfeldt-Jakob disease. What causes these is an abnormal protein called a "prion". Tissues from the brain and spine contaminate and mix with other parts and non-infected cows at the slaughterhouse. The cows are getting this because people have been grinding up sick cows and feeding them back to more cows. This is not the way nature intended, so mutations have arrived.

Tags: disease, madcow

New Clues to Prion Infectivity

Thu, 06 Sep 2007 05:41:10 GMT

clipped by: y_qadash
clipper's remarks: The ramifications are primarily this:
This is evidence of why CJD has received misdiagnoses so frequently. Cases of Alzheimer's and other degenerative diseases are likely to be later identified as as Mad
Cow or CJD.
Where'd I learn this?
Check out my Blog and find out
www.OkieLogic.com

Clip Source: www.hhmi.org

Detailed structural studies have revealed new insights into why the same prion protein can have different properties and be either weakly or strongly infectious.

Tags: science, pandemic, news, medical, god, disease, bugs, atheist

cjdsurveillance.com

Wed, 05 Sep 2007 18:27:08 GMT

clipped by: shankargallery

Clip Source: www.cjdsurveillance.com

The National Prion Disease Pathology Surveillance Center (NPDPSC) was established in 1997 at the Division of Neuropathology of Case Western Reserve University. Several European countries also have established surveillance centers to monitor the occurrence of prion diseases, or spongiform encephalopathies, in response to the epidemic of Bovine Spongiform Encephalopathy (BSE), also known as “mad cow disease,” which occurred in the United Kingdom during the 1980s.

Tags: prion

Potential New Therapy For The Treatment Of Alzheimer's

Mon, 27 Aug 2007 14:24:22 GMT

clipped by: dorine
clipper's remarks: ...and other brain diseases.

Clip Source: www.sciencedaily.com

Science Daily — Researchers have provided new information about how communication among neurons may be prevented from deteriorating in conditions such as Alzheimer's disease (AD). The new results may lead to new therapies for the treatment of not only AD but also motor neuron diseases and prion diseases.

Most current research efforts to find a treatment for AD and similar conditions focuses on what happens to the main part -- or body -- of a neuron, but recent studies have examined how neuronal communication is impaired in human diseases such as AD. When a neuron interacts with another neuron, it uses an extension called an axon that releases chemicals, which diffuse across a tiny gap between the neurons called a synapse and crosses the other neuron.

Deterioration of synapses and axons can be delayed thanks to a protein created by a gene called the slow Wallerian degeneration (Wlds) gene.

Tags: alzheimer's, health, therapy, new discovery

Prions of fungi

Sun, 19 Aug 2007 16:55:23 GMT

clipped by: shankargallery

Clip Source: microbiologybytes.wordpress.com

Prions of fungi

Posted by ajcann on August 17th, 2007

[URE3] is a prion of the nitrogen catabolism regulator Ure2p

[PSI+] is a prion of the translation-termination factor Sup35p, which has a parallel beta-sheet structure.

[PIN+] is a prion of Rnq1p (function unknown)

[Het-s] is a prion of the heterokaryon incompatibility protein HETs; this prion of apparently benefits its host (Podospora anserina), whereas the [URE3] and [PSI+] prions of Saccharomyces cerevisiae are detrimental.

[β] is a prion of vacuolar protease B

[C] is a prion of a mitogen-activated protein kinase kinase kinase

There are six known prions of fungi, including four self-propagating amyloids and two enzymes that are necessary to activate their inactive precursors:

elated:

Tags: prion

Canadian researchers identify new prion protein

Sat, 18 Aug 2007 14:45:55 GMT

clipped by: shankargallery

Clip Source: www.ctv.ca

Canadian researchers identify new prion protein

The scientists, led by Dr. David Westaway at the University of Alberta's Centre for Research in Neurodegenerative Diseases, report that they have isolated a prion protein called Shadoo, which is found in the brain cells of mice, humans and probably other mammals.

The protein appears to protect neurons, they reported in an article in the Embo Journal (the acronym stands for the European Molecular Biology Organization). In mice infected with a prion disease, Shadoo starts to disappear, suggesting a lack of this protein contributes to the damage done by the disease, Westaway said in an interview from Edmonton.

He said there is no evidence Shadoo triggers disease itself, but that it may "aid and abet" the disease process.

Tags: prion